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Point mutant mice are gene knockout mouse models in which one or more nucleotides are replaced by mutant nucleotides in the mouse genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases. CRISPR / Cas9 technology provides a very efficient tool to generate point mutations in mouse models, to generate precise nucleotides substitutions at target sites.
The CRISPR/Cas9 PlatformCB, one of the leading gene-editing biology companies, has successfully obtained >200 mouse models with very high efficiency and success rate by using CRISPR/Cas9-mediated genome editing technology. We are committed to providing you with high-quality CRISPR/Cas9 gene-editing services, including custom CRISPR/Cas9 design strategy, and trusted verification methods. We guarantee delivery of at least 2 founders or 3 F1 mice and complete within 3-4 months.